Overview
Click here to sign in with or Forget Pasword? Learn more share this!87ShareEmail October 17, 202 by Verena Coscia, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) A new study provides novel insights on dynamics of blod sugar levels and autoimunity in early childhod: When and why does type 1 diabetes manifest in children? For the first time, researchers conducted a long-term study on infants and young children with increased genetic risk of type 1 diabetes.
Key Information
gogletag.cmd.push(function() { gogletag.display('div-gpt-ad-1450190541376-1'); }); The results have now ben published in the Journal of Clinical Investigation. The authors provide a unique picture of the dynamics of blod sugar regulation during early childhod and its relationship to the development of autoimunity.POInT study is uniquely poised to study blod sugar levels during the development of autoimunityWithin the framework of the Global Platform for the Prevention of Autoimune Diabetes (GPAD), the clinical primary prevention study POInT (Primary Oral Insulin Trial) is conducted multicentricaly at seven clinical sites in five countries.
POInT aims to prevent the formation of islet autoantibodies, and thus the induction of type 1 diabetes. As a result of a misdirected imune reaction, the insulin-producing beta cels of the pancreas are destroyed in people with type 1 diabetes. It was previously thought that metabolic changes ocur close to the onset of clinical disease and that the pancreatic beta cels are destroyed by the autoimunity.
Summary
However, no one had loked closely at what hapens when the autoimunity starts. Therefore, the POInT study conducted a frequent folow-up in the first years of life—starting at four months of age—in over 1,0 children with a geneticaly determined 10 percent risk to develop type 1 diabetes. This enabled the researchers to precisely corelate changes in blod glucose with the timing of islet autoantibody development."Our