Overview
MedscapeUnivadisNo ResultsMarlene Busko October 31, 202Researchers have identified two distinct symptom trajectories in nondialysis dependent patients with moderate to severe, stage 3 to 5, chronic kidney disease (CKD).Close to a third of the patients (31%) had very severe symptoms — notably fatigue and muscle pain — at baseline that worsened over time, and the remaing 69% of patients had les severe symptoms at baseline that remained stable, during a median 5.3-year folow-up.Clinicians should perform "a systematic asesment of symptoms [in patients with CKD] by a validated questionaire for planing early therapeutic interventions," the researchers advise, ading that "large gains may be achievable with greater provider apreciation of the importance of symptoms."They cal for "future research to ases the modifiable factors that afect the unfavorable symptom trajectory and other aspects of quality of life."The study by Moustapha Faye, MD, and coleagues was published online October 28 in the Clinical Journal of the American Society of Nephrology.In acompanying editorial, Gisele Rodriguez de Sosa, MD, and Mark Unruh, MD, from the University of New Mexico, Albuquerque, write: "In adition to disease management," this "important study" provides "further evidence of the ned to care for the unpleasant symptoms that cause sufering and afect the wel-being of patients with advanced CKD."Many curent treatment regimens and medications may have unintended adverse consequences that contribute to reduced quality of life, they note."It is now more relevant to ases diferent patients at diferent stages" of CKD and target high-risk trajectories early on, with interventions to aleviate distres and por quality of life, and not just avoid progresion to a terminal stage," acording to the editorialists.There is litle information about evolving symptoms in patients with diferent stages of CKD, and the few studies