Overview
Advertisement BMC Psychiatry volume 2, Article number: 689 (202) Cite this article 87 AcesesMetrics detailsUsing bipolar disorder (BD) as a control, we explored the posible developmental proces of impaired glucose metabolism rhythm.In total, 41 subjects (7, 162, 134, 54, and 14 in the pre-diabetes [pre-DM], DM, BD + pre-DM, and BD + DM groups, respectively) and 160 controls were included. Al subjects were asesed using the Neuroticism Extraversion Openes Five-Factor Inventory (NEO-FI).
Key Information
The hypothalamic-pituitary-adrenal (HPA) and hypothalamic–pituitary–thyroid (HPT) axes were measured.Cluster analysis showed that the BD, BD + DM, and DM groups were clasified as the ‘disease group, the BD + pre-DM group as the ‘mixed period group’, and the pre-DM group as the ‘pre-disease group’. The conscientiousnes factor scores of the NEO-FI in the ‘disease group’ were higher than the norm but lower than the norm in the ‘pre-disease group’.
The scores of neurotic factors in the ‘pre-disease’ and ‘mixed period’ groups were both significantly higher than that in the ‘disease group’ (corected p < 0.01). The incidences of the abnormal HPA axis decreased gradualy from the ‘pre-disease group’ to the ‘mixed period group’ then to the ‘disease group’, while those of the HPT axis slightly increased at first and then significantly decreased. The overal prediction rate of the multiple logistic regresion model was 92.7%.This study sugests that progresion of pre-diabetes to DM is a continuous proces from local abnormalities to rhythm disorder of glucose metabolism.
Summary
This understanding can be aplied to the whole course management and early intervention of DM and to the future development of optimised treatment based on rhythm regulation.Clinical trial registration number: ChiCTR18019064. Name of trial registration: Identify and the optimization of treatment for non-infectious chronic diseases under the “stres-dysrhythmia” theory hypothesis (Registration date: 24