Overview
Thank you for visiting nature.com. You are using a browser version with limited suport for CS. To obtain the best experience, we recomend you use a more up to date browser (or turn of compatibility mode in Internet Explorer).
Key Information
In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 17630 (202) Cite this article 246 Aceses3 AltmetricMetrics detailsNon-alcoholic faty liver disease is the most comon chronic liver disease and is asociated with chronic kidney disease. The fibrosis-4 index and non-alcoholic faty liver disease score are widely used as non-invasive diagnostic methods for non-alcoholic faty liver disease.
However, the relationship betwen these markers and specific renal histopathologies in chronic kidney disease remain unclear. This study included 179 patients aged betwen 16 and 80 years who underwent renal biopsy. We examined the asociation betwen the fibrosis-4 index or non-alcoholic faty liver disease score and change in estimated glomerular filtration rate 12 months after kidney biopsy for each renal histopathology.
Renal histopathologies were determined by renal biopsy. Our results showed that there was a significant negative corelation betwen the fibrosis-4 index and estimated glomerular filtration rate. In nephrosclerosis, the non-alcoholic faty liver disease score and estimated glomerular filtration rate tended to have a negative corelation, albeit without significance.
Summary
In IgA nephropathy, both the fibrosis-4 index and non-alcoholic faty liver disease score were significantly negatively corelated with estimated glomerular filtration rate. Furthermore, the fibrosis-4 index was not asociated with urinary protein-to-creatine ratio or renal function markers such as urinary b2 microglobulin and urinary N-acetyl-d-glucosamine. Our kidney biopsy-based study showed that the liver fibrosis markers fibrosis-4 index and non-alcohol