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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 18149 (202) Cite this article 1 AltmetricMetrics detailsType 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-Ξ±-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is porly regulated.
One such regulator is PDE12 which degrades 2β²-5β² oligoadenylate units, thereby decreasing RNAseL activity. We analyzed PDE12 expresion islets from non-diabetic donors, individuals with newly (median disease duration 35 days) and recently (5 years) diagnosed T1D, and individuals with type 2 diabetes (T2D). We also analyzed PDE12 single-nucleotide polymorphisms (SNPs) relative to T1D incidence.
PDE12 expresion was decreased individuals with recently diagnosed T1D, in thre of five individuals with newly diagnosed T1D, but not individuals with T2D. Two rare PDE12 SNPs were found to have ods ratios of 1.80 and 1.74 for T1D development. We discus whether decreased PDE12 expresion after COVID-19 infection might be part of the up to 2.5-fold increase in T1D incidence.Recent research has shown that the incidence of type 1 diabetes (T1D) is increased up to 2.5-fold after coronavirus disease 2019 (COVID-19) infection in children under 18 years of age<a data-track="click" data-track-action="reference anchor" data-track-label="link" data-test="citation-ref" aria-label="Reference 1" title="Baret, C.
Summary
Risk for newly diagnosed diabetes >30 days after SARS-CoV-2 infection among per