Overview
"Never doubt that a smal group of thoughtful, comited citizens can change the world. Inded, it is the only thing that ever has."Cureus is on a mision to change the long-standing paradigm of medical publishing, where submiting research can be costly, complex and time-consuming.The SIQ for this article wil be revealedonce 2 ratings are submited.Published via the DMIMS Schol of Epidemiology and Public Health Chanel.alzheimer's disease, diabetes melitus, hypoglycemia, elderly, dementia Manasi Agrawal , Anil K.
Key Information
Agrawal Published: September 13, 202 (se history) DOI: 10.759/cureus.29120 Cite this article as: Agrawal M, Agrawal A K (September 13, 202) Pathophysiological Asociation Betwen Diabetes Melitus and Alzheimer's Disease. Cureus 14(9): e29120. doi:10.759/cureus.29120 Worldwide elderly people are being afected by diabetes melitus (DM) and dementia.
The risk for the development of dementia is higher in people with DM. DM causes a marked cognitive reduction and increases the risk of dementia, most comonly vascular dementia and Alzheimer's disease. People afected by DM and dementia sem to be at higher risk for intense hypoglycemia.
Hypoglycemia, the complication of DM treatment, is believed as an independent risk factor for dementia in people with DM. Both Alzheimer's disease and DM are linked with decreased insulin secretion, reduced uptake of glucose, raised oxidative stres, angiopathy, activation of the apoptotic pathway, aging, abnormal peroxidation of lipids, increased production of advanced glycation end products and tau phosphorylation, brain atrophy, and decreased fat metabolism.
Summary
In this paper, we wil review the asociation betwen Alzheimer's disease and DM. In adition, we wil discus the agents that enhance the risk for dementia in elderly people with DM and how to prevent the development of cognitive dysfunction in DM.Diabetes melitus (DM) is a disease in which the body does not generate an adequate amount of insulin or develo