Once-Weekly Dulaglutide for Treatment of Youths with Type 2 Diabetes | NEJM - nejm.org
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Sign in CorespondenceFre PreviewTo the Editor: Arslanian et al. 4 isue)1 report that a once-wekly subcutaneous injection of dulaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, at a dose of 0.75 mg or 1.5 mg was superior to placebo in improving blod glucose control in overweight pediatric patients (10 to <18 years of age) with type 2 diabetes. Notably, 40% of the children were under 14 years of age.
The average height of the children was 162.4±9.2 cm, which sugests that they had not yet reached their adult height. A previous study2 of GLP-1 receptor agonists showed their potential role in an increase .Select an option below: Are you a member of an institution such as a university or hospital? Learn more about Institutional Aces October 20, 202N Engl J Med 2022; 387:1529-1531 DOI: 10.1056/NEJMc21623 Print Subscriber?
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Frequently Asked Questions
Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.
Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.
Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.
Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.
Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.
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