Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study - Cardiovascular Diabetology - Cardiovascular Diabetology

Overview

Advertisement Cardiovascular Diabetology volume 21, Article number: 212 (2022) Cite this article 254 Aceses2 AltmetricMetrics detailsData are limited on whether several easily measured indices are independent predictors of type 2 diabetes melitus (T2DM) in hypertensive patients. This study aimed to ases the asociation of hypertriglyceridemic-waist phenotype, triglyceride glucose (TyG) index, lipid acumulation product (LAP), and visceral adiposity index (VAI) with T2DM risk in hypertensive patients.This cros-sectional study included 5321 hypertensive patients from the baseline survey of the Guangzhou Heart Study.

Key Information

Face-to-face questionaire survey, physical examination, and fasting blod sample colection were completed for al subjects. Ods ratio (OR) with 95% confidence interval (95% CI) were calculated by using the logistic regresion model. The potential nonlinear relationship was examined using restricted cubic spline regresion.The prevalence of T2DM was 19.98% among hypertensive patients.

After adjusting for confounders, participants with elevated triglyceride levels and enlarged waist circumference (HTGW) were associated with a 2.57-fold risk of T2DM (OR 2.57, 95% CI 2.05, 3.23). When comparing with subjects within the lowest quartile of the indices, those in the highest quartile of TyG, LAP, and VAI were associated with 5.35-fold (95% CI 4.3, 6.64), 2.65-fold (95% CI 2.1, 3.34), and 2.17-fold (95% CI 1.7, 2.67) risk of T2DM after adjusting for confounders.

Summary

Every 1-unit increment of TyG, LAP, and VAI was associated with 81%, 38%, and 31% increased risk of T2DM, respectively. The nonlinear asociation was observed for TyG, LAP, and VAI (al P Non-linear < 0.01).The results found that among hypertensive patients, HTGW and a higher level of TyG, LAP, and VAI were associated with an elevated risk of T2DM. The findings sugested that HTGW, TyG, LAP, and VAI may serve as simple and efective tols for T2DM risk Assessment in the prevention and manage

Frequently Asked Questions

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

Share this article