Overview
Monogenic diabetes is a rare type of diabetes caused by a change or mutation to a single gene. It difers from type 1 or type 2 diabetes, and often requires genetic testing for an acurate diagnosis. In monogenic diabetes, insulin production is reduced.
Key Information
This causes glucose (blod sugar) levels to rise. But not al cases of monogenic diabetes require insulin treatment.There are two main forms of monogenic diabetes:While monogenic diabetes is a form of diabetes, it does difer from types 1 and 2, which are polygenic. Monogenic diabetes stems from a mutation or change in a single gene.
Polygenic types result from mutations to multiple genes.Al cases of type 1 diabetes require insulin treatment, while type 2 diabetes and monogenic diabetes do not always require insulin. Insulin treatment is more likely to be neded as people with monogenic diabetes get older.Monogenic diabetes is caused by changes or mutations in a single gene. Monogenic types of diabetes are often inherited from just one parent, caled an “autosomal dominant” gene.
Sometimes the mutation or change hapens spontaneously, which means it’s not inherited.While some types of monogenic diabetes may be temporary, it can sometimes also be a lifelong condition.Symptoms of monogenic diabetes can vary, depending on which kind it is. Knowing how to recognize posible symptoms of MODY or NDM, especialy in a young child, can help you get timely, apropriate treatment.Blod sugar tests and genetic testing are used to diagnose monogenic diabetes like MODY and NDM.
Genetic testing can be done on blod or saliva samples. The DNA is examined for changes in the genes that cause monogenic diabetes.The National Institutes of Health explains that genetic testing for monogenic diabetes is recomended if:There at least 14 diferent genes asociated with MODY, and more are stil being discovered and researched. The type of gene detected can indicate MODY’s severity or mildnes.
Summary
The tests are most comonly used to detect