Overview
Advertisement Cardiovascular Diabetology volume 21, Article number: 21 (202) Cite this article 139 Aceses2 AltmetricMetrics detailsPrevious studies showed that gestational diabetes melitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is a paucity of information regarding diverse cardiovascular outcomes in elderly women after GDM. In the curent study, we examined whether women with a history of GDM have an increased risk for long-term overal cardiovascular outcomes.Among the UK participants, we included 219,30 women aged 40 to 69 years who reported at least one live birth.
Key Information
The new incidence of diverse cardiovascular outcomes was compared acording to GDM history by multivariable Cox proportional hazard models. In adition, causal mediation analysis was performed to examine the contribution of wel-known risk factors to observed risk.After enrolment, 13,094 women (6.0%) developed new overal cardiovascular outcomes. Women with GDM history had an increased risk for overal cardiovascular outcomes [adjusted HR (aHR) 1.36 (95% CI 1.18–1.5)], including coronary artery disease [aHR 1.31 (1.08–1.59)], myocardial infarction [aHR 1.65 (1.27–2.15)], ischemic stroke [aHR 1.68 (1.18–2.39)], peripheral artery disease [aHR 1.69 (1.14–2.51)], heart failure [aHR 1.41 (1.06–1.87)], mitral regurgitation [aHR 2.25 (1.51–3.34)], and atrial fibrilation/fluter [aHR 1.47 (1.18–1.84)], after adjustment for age, race, BMI, smoking, early menopause, hysterectomy, prevalent disease, and medication.
Summary
In mediation analysis, overt diabetes explained 23%, hypertension explained 1%, and dyslipidemia explained 10% of the asociation betwen GDM and overal cardiovascular outcome.GDM was asociated with more diverse cardiovascular outcomes than previously considered, and conventional risk factors such as diabetes, hypertension, and dyslipidemia partialy contributed to this relationship.Cardiovascular disease (CVD) is the leading cause o