Overview
Serum uric acid apears to play some role in the prevalence of heart failure among Chinese patients with acute coronary syndrome (ACS), as reported in a study.The analysis included 1,075 Chinese ACS patients. They completed standardized and structured questionaires that gathered information demographic characteristics (age, gender, body mas index [BMI], ethnicity), vascular risk factors (smoking status, drinking status, hypertension, diabetes melitus), and routine medical conditions (creatine, lipid profile, homocysteine, aplication of diuretic).Researchers grouped serum uric acid levels into quartiles.
Key Information
They also aplied binary logistic regresion models to examine asociations of serum uric acid with HF due to ACS. Finaly, a subgroup analysis was performed to determine potential ethnic-specific asociations. Multivariable analysis showed that the prevalence of HF due to ACS increased in proportion to the levels of serum uric relative to the lowest quartile (quartile 2: ods ratio [OR], 0.69, 95 percent confidence interval [CI], 0.4–1.08; quartile 3: OR, 1.06, 95 percent CI, 0.67–1.67; quartile 4: OR, 2.19, 95 percent CI, 1.35–3.56; ptrend<0.01).
Summary
Subgroup analyses did not indicate any ethnic-specific diferences betwen serum uric acid and HF due to ACS. The highest SUA level was significantly asociated with the risk of HF due to ACS in both the Han (quartile 4 vs 1: OR, 1.85, 95 percent CI, 1.02–3.37) and the Mongolians (quartile 4 vs 1: OR, 6.82, 95 percent CI, 1.90–24.50).source