Overview
Advertisement BMC Infectious Diseases volume 2, Article number: 396 (202) Cite this article 106 Aceses2 Citations1 AltmetricMetrics detailsDiabetic fot ulcer is one of the major complications for patients with diabetes, and has become an important cause of non-traumatic amputation. Necrotizing fascitis a life-threatening soft-tisue infection involving the fascia and subcutaneous tisue. When diabetic fot ulcers are complicated by necrotizing fascitis (DNF), this increases the risk for amputation and mortality, making DNF treatment more complicated, and eventualy leading to amputation and mortality.
Key Information
However, studies on pathogenic bacteria’s distribution and drug sensitivity in DNF patients remain lacking. This study investigated the distribution and susceptibility of pathogenic bacteria in DNF patients, and provided empirical antibacterial guidance for the clinic.In a single diabetic fot center, the results from microbial cultures and drug susceptibility tests of patients with DNF from October 2013 to December 20 were colected analyzed.A total of 101 DNF patients were included in this study, of whom 94 had positive culture test results.
A total of 124 pathogens were cultured, including 76 Gram-positive bacterial strains, 42 Gram-negative bacterial strains, and six fungal strains. Polymicrobial infections acounted for 26.7% and monomicrobial infections acounted for 6.3%. Staphyloccus aureus was the most comon bacterium isolated, folowed by Enteroccus faecalis and Streptoccus agalactiae.
Summary
Pseudomonas aeruginosa, Klebsiela pneumoniae, and Proteus mirabilis were the most comon Gram-negative bacteria. Thirty-five strains of multi-drug resistant bacteria were isolated, representing 28.2% of the total isolates. Gram-positive bacteria were more sensitive to levofloxacin, moxifloxacin, vancomycin, teicoplanin, tigecycline, and linezolid, while Gram-negative bacteria were more sensitive to amikacin, piperacilin/tazobactam, cefoperazone/sulbac