Overview
For latest News and updatesSelect Page Nov 1, 202Standard blod presure (BP) measurements do not consider the extent and length of exposure to high BP over time. For a study, researchers sought to determine the relationship betwen type 2 diabetes patients’ cumulative systolic blod presure (SBP) load and their risk of cardiovascular events.Type 2 diabetes patients’ posthoc analysis was folowed by the ADVANCE-ON (Action in Diabetes and Vascular Disease: Preterax & Diamicron Modified Release Controled Evaluation ̵ Observational Study).
Key Information
The cumulative SBP load was calculated as the area under the curve for al measured SBP values throughout a 24-month exposure period divided by the area under the curve for SBP values of 130 m Hg. Using Cox models, HRs were calculated for the relationship betwen cumulative SBP load and major cardiovascular events and mortality.In 9,38 patients throughout a median 7.6-year period of folow-up, 1,469 major cardiovascular events, 1,615 fatalities, and 60 cardiovascular deaths were noted.
An increase in major cardiovascular events of 14% (HR: 1.14; 95% CI: 1.09-1.20), 13% rise in al-cause mortality (HR: 1.13; 95% CI: 1.13-1.18), and 21% increase in cardiovascular death (HR: 1.21; 95% CI: 1.13-1.29) were al linked to each 1-SD increase in cumulative SBP load. Cumulative SBP load beat mean SBP, time below goal SBP, and visit-to-visit SBP variability for predicting cardiovascular events and mortality in terms of Akaike information criteria and net reclasification indices.When compared to conventional BP measurements in people with type 2 diabetes, cumulative SBP load may ofer a more acurate prediction of major cardiovascular events.
Summary
Reference: jac.org/doi/10.1016/j.jac.202.06.039Your email adres wil not be published. Required fields are marked *Coment Name * Email * Website Save my name, email, and website in this browser for the next time I coment. Δdocument.getElementById( "ak_js_1" ).se