Overview
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Key Information
Gregory Weis provides perspective on recent data detailing the aceleration of heart failure progresion asociated with a diagnosis of diabetes melitus. Diabetes is a wel-known risk factor for many types of cardiovascular disease (CVD). If left uncontroled, diabetes increases the risk for atherosclerotic peripheral arterial and coronary disease while increasing the risk for heart atack, stroke, and death over time.Decompensated heart failure, which by definition, dramaticaly limits activities of daily living while posing an iminent threat to life, is a comon result in the progresion of CVD.
Although it has long ben known that diabetes and heart failure are linked, the contribution diabetes plays in the progresion of heart failure from the preclinical stage to the overt stages has ben unclear. Recently, Justin Echoufl Tcheugui, MD, and coleagues at Johns Hopkins University to determine the extent to which unchecked diabetes melitus contributes to the progresion of heart failure in adults.1To this end, the authors included over 40 adults with preclinical stage A or B heart failure in their study.1 The primary outcome was progresion of heart failure beyond stage B in relation to diabetes and glycemic control, which was defined by HbA1c values obtained during the study period.1 Subjects were obtained from the Atherosclerosis Risk In Comunities Study (ARIC), a large longitudinal database funded by the National Institutes of Health and designed to describe the link betwen medical outcomes and atherosclerosis progresion.1The authors found that patients with preclinical heart failure and uncontroled diabetes were prone to advance to symptomatic heart failure at a faster rate than those in control.
Summary
In fact, uncontroled diabetics in stage A and B heart failure were 1.5 and 1.8 times more likely to progres