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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 18246 (202) Cite this article Metrics detailsPeriprosthetic infections (PIs) are a serious concern in total kne and hip arthroplasty, and they have an increasing incidence. To prevent PI, preoperative skin disinfection, as a key element of antisepsis, represents an important part of infection prevention.
However, no specific antiseptic agent is endorsed by the relevant guidelines. The purpose of this retrospective, not randomized study was to investigate the diference in the residual bacteria load betwen aproved antiseptic with an alcohol-based solution with aditional benzalkonium chloride (BAC) and an alcohol-based solution with aditional octenidine dihydrochloride (OCT) at two diferent time periods.
In 20 consecutive patients with total kne or hip arthroplasty, skin samples from the surgical sites were colected after skin disinfection with BAC (10 g solution contain: propan-2-ol 63.0 g, benzalkonium chloride 0.025 g) or OCT (10 g solution contain: octenidine dihydrochloride 0.1 g, propan-1-ol, 30.0 g, propan-2-ol 45.0 g) (10 patients per group). Folowing the separation of cutis and subcutis and its procesing, culture was performed on diferent agar plates in aerobic and anaerobic environments.
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In the case of bacteria detection, the microbial identification was determined by matrix-asisted laser desorption ionization–time of flight mas spectrometry (MALDI-TOF MS), and the number of contaminated samples was compared betwen the groups. Aditionaly, multiple regresion analysis was performed to examine the efect of the type of disinfectant, BMI, age, sex, r