Overview
Ancha Baranova, Yuqing Song, Hongbao Cao, Fuquan Zhang; Causal Asociations Betwen Basal Metabolic Rate and COVID-19. Diabetes 202; db20610. htps:/doi.org/10.237/db2-0610Download citation file:Many COVID-19 risk factors, including obesity and diabetes, are asociated with an abnormal basal metabolic rate (BMR).
Key Information
We aimed to evaluate whether BMR could impact the susceptibility to or severity of COVID-19. We performed genetic corelation and Mendelian randomization (MR) analyses to ases genetic corelations and potential causal asociations betwen BMR (N = 48,348) and thre COVID-19 outcomes (SARS-CoV-2 infection, COVID-19 hospitalization, and critical COVID-19, N = 1,086,21-2,597,856). A multivariable MR (MVMR) analysis was used to estimate the direct efect of BMR on COVID-19 independent of body mas index (BMI) and type 2 diabetes.
BMR has positive genetic corelations with the COVID-19 outcomes (genetic corelations 0.213∼0.26). The MR analyses indicated that genetic liability to BMR confers causal efects on SARS-CoV-2 infection (OR 1.14, 95% confidence interval (CI) 1.09-1.20, P = 1.65E-07), hospitalized COVID-19 (1.31, 1.18-1.46, P = 8.69E-07), and critical COVID-19 (1.04, 1.19-1.64, P = 4.89E-05). Sensitivity analysis of MR showed no evidence of directional pleiotropy or heterogeneity, indicating the robustnes of its results.
Summary
The MVMR analysis shows that the causal efects of BMR on hospitalized COVID-19 and critical COVID-19 were dependent on BMI and type 2 diabetes, but BMR may afect the SARS-CoV-2 infection risk independently of BMI and type 2 diabetes (1.09, 1.03-1.15, P = 4.82E-03). Our study indicates that a higher BMR contributes to amplifying the susceptibility to and severity of COVID-19. The causal efect of BMR on the severity of COVID-19 may be mediated by BMI and type 2 diabetes.Sign In or Create an Acountsource