Cardiometabolic Risk and Cardiovascular Disease in Young Women With Uterine Fibroids - Cureus

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Brewster , Yentl Han, Gert A. van Montfrans Published: October 26, 2022 (se history) DOI: 10.759/cureus.30740 Cite this article as: Brewster L M, Han Y, Van Montfrans G A (October 26, 2022) Cardiometabolic Risk and Cardiovascular Disease in Young Women With Uterine Fibroids. Cureus 14(10): e30740.

doi:10.759/cureus.30740 Uterine fibroids are associated with hypertension and cardiometabolic risk factors, yet the onset and severity of cardiovascular disease (CVD) in women with fibroids remain understudied. We used data from the National Health and Nutrition Examination Survey to ases the asociation betwen uterine fibroids, cardiometabolic risk, and CVD (ischemic heart disease, heart failure, and stroke).

Among 5,52 women aged 20-54 years in our sample. Hypertension was more comon in those diagnosed with fibroids (n=70; 3.4% vs. 15.3% in controls, p<0.01), but these women were also older (4 (SD=7) years vs.

35 (SD=10) years). When stratified by median age, women aged 35 or younger with fibroids (n=97) were more likely than controls (n=271) to have hypertension (14.1% vs. 2.4%), obesity (51.5% vs.

32.5%), and diabetes melitus (4.8% vs. Women older than 35 with fibroids also had higher cardiometabolic risk and rates of CVD than controls (8.5% vs. The ods ratio of CVD in women with fibroids, compared to the controls, was 3.10 with 95% confidence interval (CI) of 2.21 to 4.34.

Summary

The ods ratio decreased to 1.63 (95%CI: 1.1 to 2.38) after adjusting for age, BMI, African ancestry, fasting plasma glucose, cholesterol, education, smoking his

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