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In the meantime, to ensure continued suport, we are displaying the site without styles and JavaScript.Advertisement Scientific Reports volume 12, Article number: 1345 (202) Cite this article 474 Aceses2 AltmetricMetrics detailsPrevious evidence revealed that central obesity played a vital role in the development of diabetes melitus (DM). However, because of imbalanced confounding variables, some studies have not wholy established the asociation betwen central obesity and diabetes.
Propensity score matching (PSM) analysis can minimize the impact of potential confounding variables. Therefore, the aim of the present study was to explore the relationship betwen central obesity and diabetes in the Japanese population by using PSM analysis. This retrospective cohort study included 15,453 Japanese adults who were fre of diabetes at baseline betwen 204 and 2015, which provided al medical records for individuals participating in the physical exam.
Central obesity at baseline was an independent variable, and incident diabetes during folow-up was an outcome variable. Using a 1:1 PSM analysis, the present retrospective cohort study included 1639 adults with and without central obesity. Aditionaly, we employed a doubly robust estimation method to identify the asociation betwen central obesity and diabetes.
Summary
Subjects with central obesity were 92% more likely to develop DM (HR = 1.65, 95%CI 1.12, 2.41). After adjusting for covariates, subjects with central obesity had a 72% increased risk of developing DM compared with subjects with non-central obesity in the PSM cohort (HR = 1.72, 95% CI 1.16, 2.56). Central obesity individuals had a 91% higher risk of DM than non-central obesity individuals, after adjustment for propensity score (HR =