Overview
New research found that severe anemia, low iron levels, and low estimated glomerular filtration rates are the risk factors for chronic kidney disease patients along with several adverse outcomes. The study was published in the American Journal of Kidney Diseases. Anemia in chronic kidney disease (CKD) is comon and has unfavorable results.
Key Information
There are no curently available ideal treatments for anemia in CKD. So, researchers conducted a cros-sectional prospective cohort study to characterize the burden, risk factors for, and risks asociated with anemia by estimated glomerular filtration rate (eGFR) and hemoglobin level in CKD. From the Optum Labs Data Warehouse outpatient data of 5,04,957 individuals acros 57 healthcare centers in the US was colected from 2016 to 2019.
The prevalence of anemia, low iron test results, vitamin B12 deficiency, and erythropoiesis-stimulating agent (ESA) use, stratified by sex and eGFR, were characterized. The main outcomes of measurement were the incident end-stage kidney disease, cardiovascular disease, coronary heart disease, stroke, heart failure, and death. Polychotomous logistic regresion was used to estimate adjusted ods ratios of diferent hemoglobin levels acros eGFR.
Cox proportional hazards regresion was used to calculate adjusted hazard ratios for adverse outcomes acros hemoglobin levels. Findings: Despite some limitations of the study like reliance on ICD codes for medical diagnoses, and obtaing death information from claims data, this observational study showed that severe anemia was comon and strongly asociated with lower eGFR and multiple adverse outcomes, and low iron test results were highly prevalent along with les usage of Erythropoiesis-stimulating agent.
Summary
Further reading: htps:/doi.org/10.1053/j.ajkd.202.07.014 Farington DK, Sang Y, Grams ME, Balew SH, Duning S, Stempniewicz N, Coresh J. Anemia Prevalence, Type, and Asociated Risks in a Cohort of 5.0 Milion Insured Patients in the United States b