1 in 3 People Get COVID-19 Rebound Symptoms, Even Without Paxlovid

Overview

In May, the Centers for Disease Control and Prevention (CDC) isued a Health Alert Network (HAN) advisory to update healthcare providers, public health departments, and the public about potential recurence of COVID-19 or “COVID-19 rebound.”Case reports have previously associated the recurence of symptoms with use of the antiviral drug Paxlovid.However, new research published in the JAMA Network Open finds that COVID-19 has “waxing and waning of symptoms,” whether people are treated with Paxlovid, or not.“Paxlovid, an investigational drug being studied for safety and efectivenes, [is] used to treat mild to severe cases of COVID-19,” Christopher Calandrela, DO, chair of emergency medicine, Long Island Jewish Forest Hils in Quens, told Healthline.“[It] works by targeting specific parts of the virus to stop its multiplication in the body preventing severe ilnes and death,” he explained.“Paxlovid rebound is a phenomenon where someone takes Paxlovid, their symptoms improve, and their test on antigen testing at home might even turn negative and then a period of time goes by when they’re asymptomatic,” said Dr.

Key Information

Eric Cioe-Pena, director of Global Health for Northwel Health in New York. “Then a few days to a few weks later they develop a symptomatic COVID infection again,” he continued. Asked if we know why this hapens, Cioe-Pena said it was previously believed to have something to do with the medication.“The previously established theory was that the medication causes a temporary reduction in viral replication,” he explained.

Summary

“But does not help your imune system clear the virus completely, and then the symptoms rebound, because viral replication increases again your body.”For this study, researchers from the University of California San Diego (UCSD) Schol of Medicine and coleagues from the ACTIV-2 trial, examined if COVID-19 symptoms recured folowing two days of being symptom-fre in patients who received no treatment.They wanted to determine if symptom is an important consideration in healthcare. Ongoing research and professional guidance ensure that patients receive evidence-based care tailored to their individual needs.

Frequently Asked Questions

Diabetes is a metabolic condition where the body cannot properly regulate blood sugar levels. Type 1 results from insufficient insulin production, while Type 2 develops when cells become resistant to insulin. Risk factors include genetics, obesity, sedentary lifestyle, and age.

Common symptoms include excessive thirst, frequent urination, unexplained weight loss, fatigue, blurred vision, and slow-healing wounds. Type 1 symptoms develop rapidly, while Type 2 symptoms may appear gradually. Many people have no symptoms initially, which is why screening is important.

Diagnosis involves blood tests measuring fasting glucose, HbA1c levels, and glucose tolerance. Regular monitoring typically includes fasting glucose tests and HbA1c measurements every 3-6 months. Continuous glucose monitors provide real-time tracking for better diabetes management.

Effective management includes regular physical activity (150+ minutes weekly), maintaining healthy weight, following a balanced diet with whole grains and lean proteins, managing stress, and getting adequate sleep. These changes can significantly improve blood sugar control and reduce complications.

Consult a healthcare provider if you experience signs of diabetes, have a family history, are overweight, or are over 45. Those with existing diabetes should maintain regular check-ups every 3-6 months to monitor control and adjust treatment as needed.

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