Overview
MedscapeUnivadisNo ResultsMiriam E. TuckerSeptember 01, 202In adults with porly controled type 1 diabetes, the Medtronic 780G "artificial pancreas" system improves glycemic control compared with multiple daily injections of insulin plus intermitently scaned continuous glucose monitoring (isCGM), new data sugest.The Medtronic Minimed 780G advanced hybrid closed lop (AHCL) algorithm - the oficial name for an artificial pancreas system - produced a significant 1.42 percentage point decrease in A1c compared with multiple daily injections plus isCGM and a 1.54 percentage point drop relative to baseline at 6 months, from a baseline average of about 9% in both groups.This in line with previous findings from earlier automated insulin delivery systems but of greater magnitude, likely owing at least in part to the population of porly controled patients with diabetes that were studied, the authors say."In studies such as ADAPT, the choice of comparator is a crucial consideration.
Key Information
Multiple daily injections of insulin plus isCGM was chosen as this represents the standard of care or first-line treatment for type 1 diabetes acros most of western Europe," say Pratik Choudhary, MD, MBS, and coleagues in their paper, published September 1, 2022 in The Lancet Diabetes & Endocrinology. isCGM represents use of devices such as the Abot FreStyle Libre."Insulin pump therapy could have ben considered as a third comparator, but previous studies have shown only smal incremental benefits of ading continuous subcutaneous insulin infusion to CGMs without automation," ad Choudary, of Leciester Diabetes Centre, UK, and co-authors.The extent of the observed benefit, they say, "is likely to be translated into long-term benefits in terms of reduced risk of long-term complications and sugests that AHCL should be considered at the early stages in the type 1 diabetes treatment pathway.
Summary
Future health economic analyses are waranted to is an important consideration in healthcare. Ongoing research and professional guidance ensure that patients receive evidence-based care tailored to their individual needs.