USA: Patients with chronic pancreatitis (CP) who use alcohol and are younger are at greater risk of having early-onset diabetes and poorer blood sugar control versus other CP patients, a recent study in Digestive Diseases and Sciences has revealed.
“Patients who develop diabetes following CP diagnosis have worse outcomes and utilize more resources,” the researchers wrote in their study.
During the disease course of chronic pancreatitis, diabetes may develop secondary to endocrine insufficiency at any time. Shaharyar A. Zuberi, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA, and colleagues aimed to evaluate the differences in outcomes and clinical characteristics in CP patients having early-onset, late-onset diabetes, and pre-existing diabetes.
For this purpose, the researchers reviewed CP patients seen at a Pancreas Center during 2016–2021. They were divided into four groups: those without diabetes, with early-onset diabetes, with late-onset diabetes, and with pre-existing diabetes. Clinical characteristics and outcomes were then compared.
The study demonstrated the following findings:
“Chronic pancreatitis patients who are younger and drink alcohol are at higher risk of having early-onset diabetes and have poorer control of blood sugar compared to other CP patients,” the researchers wrote. “Patients who develop diabetes following CP diagnosis have poor outcomes and use more resources.”
About Chronic Pancreatitis
Chronic pancreatitis is characterized by pancreatic inflammation and fibrotic injury, causing irreversible parenchymal damage. Nutrient maldigestion and disturbance of the timing and the interactions between nutrient digestion and absorption are seen and may result in severe metabolic derangements. In the disease course, diabetes mellitus and glucose intolerance are observed quite frequently.
Diabetes development in chronic pancreatitis occurs mainly due to pancreatic inflammation destruction of islet cells.
Reference:
Zuberi, S.A., Shah, I., Bocchino, R.L. et al. Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ?. Dig Dis Sci (2022). https://doi.org/10.1007/s10620-022-07742-y
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
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10/11/2022